CASE.EDU:    HOME | DIRECTORIES | SEARCH
case western reserve university

DEPT. OF EPIDEMIOLOGY
& BIOSTATISTICS

 

COURSES

Divisions
Epidemiology Courses
Biostatistics Courses
Genetic and Molecular Epidemiology Courses
Health Services Research Courses
Computing Courses


Epidemiology Courses
EPBI 410 - Principles of Biomedicine for Epidemiology and Biostatistics (3)
Basic principles of human biology, biochemistry and immunology necessary for understanding the biomedical issues in epidemiology and biostatistics.

EPBI 411 - Introduction to Behavioral Medicine (3)
Using a biopsychosocial perspective, an overview of the measurement and modeling of behavioral, social, psychological, and environmental factors related to disease prevention, disease management, and health promotion is provided. Instructor: Scott Frank, M.D.

EPBI 433 - Community Interventions and Program Evaluation (3) (Also listed as MPHP 433)
This course prepares students to design, conduct, and assess community-based health interventions and program evaluation. Topics include assessment of need, evaluator/stakeholder relationship, process vs. outcome-based objectives, data collection, assessment of program objective achievement based on process and impact, cost-benefit analyses, and preparing the evaluation report to stakeholders.

Issues in the design, organization and operation of randomized controlled clinical trials and intervention studies. Topics covered will include: legal and ethical issues in the design; application of concepts of controls, masking and randomization; steps required for quality data collection; monitoring for evidence of adverse or beneficial treatment effects; elements of organizational structure; sample size calculations and data analysis procedures; common mistakes.
Prerequisites: Basic epidemiology and biostatistics.

EPBI 486 - Epidemiology of Violent Behavior (2)
Consideration of the epidemiology of injuries caused by violent behavior. The course will be based on analyses of current literature and emphasize the use of epidemiologic tools in studying fatal and non-fatal injuries due to interpersonal and intrapersonal violence. It will consider 1) methods of surveillance of injuries to monitor changing rates and define high-risk groups; 2) epidemiologic analytic to define risk factors and to suggest possible intervention strategies; and 3) the development and evaluation of specific interventions. Students will be exposed to national and local databases. They will be expected to make oral and written presentations from analyses of these databases or of current literature. Presentations of efforts in violence reduction by workers in the field will be included.

EPBI 487 - Pharmacoepidemiology (3)
Basic principles underlying pharmacoepidemiology, including study design and sample size; ethical issues in drug testing and approval; the use of large databases for research; and pharmacoeconomics.
Prerequisite: EPBI 490, EPBI 491.

Epidemiologic principles and methods needed to understand population-based statements of illness and health. Descriptive epidemiology, analytic epidemiology and epidemiologic inference. Classification, morbidity and mortality rates, sampling, screening, epidemiologic models, field trials, controlled epidemiologic surveys, sources of bias and causal models. Instructor: Christopher C. Whalen, M.D.
Prerequisite: STAT 201, STAT 207, STAT 312 or consent of instructor.

EPBI 491 - Epidemiology: Case-control Studies (3)
This course will cover the methods used in the conduct of epidemiologic research. Topics include: case control studies, cohort studies, clinical trials, cross-section studies, exposure measurement, subject selection, validity, reliability, sample size and power, effect modification, confounding, bias, chance, risk assessment, frequency matching, matching, meta-analysis. Analysis of data sets will be given as well. Instructor: Daniel Tisch, Ph.D.
Prerequisite: EPBI 431, EPBI 490

EPBI 492 - Epidemiology: Cohort Study Design and Analysis (3)
The course focuses on strategies for model building. Topics include the analysis of cohort and case-control studies where the emphasis is on risk estimation. Students are expected to analyze a database obtained from a cohort study of the effects of maternal alcohol drinking on outcomes of pregnancy and from a related nested case-control study. The analysis of survival data focuses on parametric and non-parametric techniques and utilizes data from an ongoing study of quality of life of patients on kidney dialysis. In addition to regular class assignments, students are expected to write a report on each of the databases and present results to the class. Instructor: Ajay Sethi, Ph.D.
Prerequisite: EPBI 432, EPBI 491 or consent of instructor.

EPBI 493 - The Epidemiology of Cardiovascular Disease (3)
This course will familiarize students with the known factors contributing to various forms of cardiovascular disease in industrialized nations. It will also introduce the concept of prevention and the influence of behavior modification upon patient's health.
Prerequisite: EPBI 490 or equivalent.

The epidemiology, prevention and control of representative infectious disease models. Emphasis on the triad of agent, host and environment and the molecular and genetic basis of agent and host interaction in the population. Instructor: Christopher C. Whalen, M.D.
Prerequisite: EPBI 490 and a microbiology course or consent of instructor.

EPBI 497 - Epidemiologic Studies of Cancer Etiology and Prevention (3)
Provides descriptive epidemiology of most major types of cancer. Examines current knowledge of the role that host factor, lifestyle, chemicals, radiation, viruses, familial factors and benign diseases play in the etiology of various cancers, as determined from studies of human populations. Applications of epidemiologic principles to programs of primary, and secondary cancer prevention.
Prerequisite: EPBI 490

EPBI 498 - Cancer Epidemiologic Analyses of National Data (3)
Practical experience in analysis of cancer data including: defining a hypothesis, conducting a literature search, designing appropriate analyses, analyzing the data, and reporting the findings. Students analyze cancer data sets currently on file, such as National Cancer Institute's Surveillance, Epidemiology, and End Results.
Prerequisites: EPBI 432 and EPBI 491

EPBI 501 - Student Seminar (0)
Students and faculty have the opportunity to meet on a weekly basis to discuss papers in the literature. Each week a paper is reviewed in detail by a graduate student in a formal presentation. Discussion of the strengths and weaknesses of the work gives insights into the complexities of investigations in the Public Health arena. Instructor: Alfred A. Rimm, Ph.D.

EPBI 508 - Ethics, Law, and Epidemiology (3)
This course is designed to provide epidemiology students with basic knowledge about the legal system and its impact on the work that they will be doing as epidemiologists. Subject areas include an overview of the legal system, designing the conducting a study, appearance as an expert witness, and the drafting of rules and legislation. Students should have a basic knowledge of study design and analytic techniques. Instructor: Sana Loue, Ph.D.

EPBI 592 - Special Topics in Epidemiology (3)
Vaccine development, epidemic models; nutritional epidemiology, genetic epidemiology; opportunistic infections; nosocomial infections; prevention strategies.

EPBI 601 - Masters Project Research (credit as arranged)

EPBI 651 - Thesis M.S. (credit as arranged)

EPBI 701 - Dissertation Ph.D. (credit as arranged)


Biostatistics Courses
This course is designed to introduce students to the use of computers for development of statistical investigation and provide familiarity with different types of statistical applications and software. Topics include an overview of the UNIX operating system, SAS, and SPSS software packages. Using SAS in the UNIX and Windows environment will be covered in detail. The main focus of this course is to develop skills in data entry, import and export, data manipulation and management, presenting descriptive statistical results and basic data analysis. Familiarity with basic statistics is not required but is useful. Extra topics introducing SAS programming code for advanced statistical analyses will be provided but not included in homework and exams. Instructor: David Bruckman, MS, MT(ASCP)

EPBI 430 - Mathematics for Biomedical Sciences (0)
This tutorial course is divided into three sections of equal length. 1) Review of the basic concepts of Algebra including quadratic equations, line and linear relations, exponential, logarithmic, trigonometric, and other relevant functions. 2) Integration techniques including integration, definite integrals, multiple integrals with change of variables, linear approximation, and series. 3) The numerical and geometric presentation of vectors and matrices. Additional topics will include: elementary matrix operations, determinants, rank, linear dependence, eigenvalues and eigenvectors and matrix inversion.

(Also listed as ANAT 431, ANES 431 and BIOL 431)
Application of statistical techniques with particular emphasis on problems in the biomedical sciences. Basic probability theory, random variables, and distribution functions. Point and interval estimation, regression, correlation, and analysis of variance. Problems whose solution involves using packaged statistical programs. Instructor: Stephen Ganocy, Ph.D.
Prerequisite: Two semesters of calculus or consent of instructor.

EPBI 432 - Statistical Methods in Biological and Medical Sciences II (3)
(Also listed as ANAT 432, ANES 432 and BIOL 432)
Methods of analysis of variance, regression and analysis of quantitative data. Emphasis on computer solution of problems drawn from the biomedical sciences. Design of experiments, power of tests, and adequacy of models. Instructor: Mireya Diaz-Insua, Ph.D.
Prerequisite: EPBI 431 or consent of instructor.

EPBI 435 - Survival Data Analysis (3)
This course will discuss the basic concepts of survival analysis including hazard function, survival function, types of censoring, Kaplan-Meier estimates, log-rank tests, and the generalized Wilcoxon tests. Parametric inference will include exponential and Weibull distributions with and without censoring. The proportional hazard and other methods of handling covariates will be discussed. Instructor: Pingfu Fu, Ph.D.
Prerequisite: EPBI 432, 481 or equivalent.

EPBI 441 - Biostatistics I (Generalized Linear Models) (3)
Selected topics in linear and logistic models. Model fitting, estimation, and measures of goodness of fit for continuous and binary data. Special problems encountered in selection of models. Instructor: Paul K. Jones, Ph.D.
Prerequisites: EPBI 432 and EPBI 481.

EPBI 442 - Biostatistics II (Nonparametric Statistics) (3)
This course deals with the basic concepts and applications of nonparametric statistics. Topics will include distribution-free statistics, one sample rank test, the Mann-Whitney and Kruskal Wallis tests, one sample and two sample U-statistics, asymptotic relative efficiency of tests, distribution-free confidence intervals, point estimation and linear rank statistics. Instructor: Paul K. Jones, Ph.D.
Prerequisite: EPBI 432 or equivalent.

EPBI 443 - Applied Multivariate Analysis (3)
This course will start with review of matrix algebra as it pertains to multivariate statistics, then proceeds to study inference about multivariate means: Hotelling's T2, MANOVA, MANCOVA, growth curves, and other linear models such as simultaneous confidence interval, multivariate multiple regression, principal components, factor analysis, cluster analysis, linear discriminant analysis and its relationship to logistic model. Instructor: J. Sunil Rao, Ph.D.
Prerequisite: EPBI 432, EPBI 481 or STAT 381 or equivalent.

EPBI 446 - Experimental Design for Biomedical Sciences (3)
This course deals with basic problems of experimental design. Topics will include completely randomized and balanced incomplete block designs, parallel group designs, Youden and Latin squares, repeated measurement studies, factorial experiments and designs for bioassays and response surfaces.
Prerequisite: EPBI 432 or consent of instructor.

EPBI 447 - Survey Sampling Methods in Health Sciences (3)
This course will discuss the basic concepts of sampling theory including simple random and systematic sampling, ratio and regression methods of estimation, stratified and cluster sampling, randomized response survey and their applications in health sciences.
Prerequisite: EPBI 432 or consent of instructor.

Issues in the design, organization and operation of randomized controlled clinical trials and intervention studies. Topics covered will include: legal and ethical issues in the design; application of concepts of controls, masking and randomization; steps required for quality data collection; monitoring for evidence of adverse or beneficial treatment effects; elements of organizational structure; sample size calculations and data analysis procedures; common mistakes. Instructor: Alfred A. Rimm, Ph.D.
Prerequisites: Basic epidemiology and biostatistics.

EPBI 453 - Categorical Data Analysis (3)
Descriptive and inferential methods for categorical data with applications: bivariate data; models for binary and multinomial response variables, with emphasis on logit models; loglinear models for multivariate data; model fitting using the maximum likelihood approach; model selection and diagnostics; and sample size and power considerations. Topics in repeated response data as time allows. Instructor: Paul K. Jones, Ph.D.

EPBI 458 - Statistical Methods for Clinical Trials (3).
This course will focus on special statistical methods and philosophical issues in the design and analysis of clinical trials. The emphasis will be on practically important issues that are typically not covered in standard Biostatistics courses. Topics will include: randomization techniques, intent-to-treat analysis, analysis of compliance data, equivalency testing, surrogate endpoints, multiple comparisons, sequential testing, and Bayesian methods. Instructor: Jeffrey M. Albert, Ph.D.

EPBI 459 - Longitudinal Data Analysis (3).
This course will cover statistical methods for the analysis of longitudinal data with an emphasis on applications in biological and health research. Topics include: exploratory data analysis, response feature analysis, growth curve models, mixed-effect models, generalized estimating equations, and missing data. Instructor: Jeffrey M. Albert, Ph.D.

EPBI 471 - Special Topics in Biostatistics (3)
Each year, different special topics are covered, such as: sampling methods, bioassay, statistical genetics, multivariate analysis, sequential analysis, stochastic models. Instructor: J. Sunil Rao, Ph.D.
Prerequisite: EPBI 442.

EPBI 480 - Introduction to Mathematical Statistics (3)
An introduction to statistical inference at an intermediate mathematical level. The concepts of random variables and distributions, discrete and continuous, are reviewed. Topics covered at an intermediate level include: expectations, variance, moments, the moment generating function; overview of some fundamental probability distributions; the central limit theorem; Bayes estimation, maximum likelihood estimators, unbiased estimators, sufficient statistics; confidence intervals, Fisher information; hypothesis testing, uniformly most powerful tests and multi-decision problems. Instructor: Courtney Gray-Mcguire, Ph.D.

EPBI 481 - Theoretical Statistics I (3)
Basic probability theory. Estimation techniques for the parameters of the basic distributions: maximum likelihood, method of moments, unbiased estimates, confidence intervals, sufficient statistics, Cramer- Rao inequality. Transformations of random variables. F and t distributions. Order statistics. Instructor: R. Pilla
Prerequisite: Math 223.
Corequisites: EPBI 431. STAT 286 or STAT 385 or consent of instructor.

EPBI 482 - Theoretical Statistics II (3)
Hypothesis testing: Neyman-Pearson Lemma, - uniformly most powerful test, likelihood ratio tests, sequential tests. Exponential families. Rao Blackwell theorem. Linear models. Nonparametric methods. Multivariate normal distributions. Likelihood, repeated sampling, conditionality and other basic principles. Instructor: R. Pilla
Prerequisite: EPBI 481.

EPBI 496 - Mathematical Models of Disease (3)
This course covers introductory concepts of stochastic processes, with particular emphasis on Poisson, renewal and Markov processes. Examples highlight the art of modeling, focusing on models of chronic and infectious disease progression and infectious disease transmission. Simulation methods are used to obtain solutions.

EPBI 501 - Student Seminar (0)
Students and faculty have the opportunity to meet on a weekly basis to discuss papers in the literature. Each week a paper is reviewed in detail by a graduate student in a formal presentation. Discussion of the strengths and weaknesses of the work gives insights into the complexities of investigations in the Public Health arena. Instructor: Alfred A. Rimm, Ph.D.

EPBI 503 - Seminar in Biostatistics (0)
Presentation of original research or recent publications by faculty and students in the area of Biostatistics. Instructor: Jeffrey M. Albert, Ph.D.

EPBI 514 - Advanced Statistical Computing (3)
Computational aspects of statistics and statistical modeling, including both graphical and analytic methods. The S programming language. The use of S and other computational tools to explore and analyze data in ways that are difficult to accomplish with standard statistical packages.
Prerequisites: EPBI 414.

EPBI 535 - Topics in Advanced Survival Analysis (3)
Topics of current research interest in survival analysis. Topics may change from year to year.

EPBI 563 - Pattern Recognition Techniques in Biomedical Research (3)
Overview of pattern recognition. Supervised learning using parametric and nonparametic statistics, linear discriminant functions, discrete and binary classification problems. Overview of syntactic methods. Introduction to neural networks. Neural approaches to supervised and unsupervised learning. Neural pattern associators and matrix approaches. Applications relevant to biomedical research.

EPBI 601 - Masters Project Research (credit as arranged)

EPBI 602 - Practicum (credit as arranged)

EPBI 651 - Thesis M.S. (credit as arranged)

EPBI 701 - Dissertation Ph.D. (credit as arranged)


Genetic and Molecular Epidemiology Courses
EPBI 448 - Genetic Analysis Programs (3)
Theory underlying software developed specifically for the genetic analysis of family data. The course will focus mainly on the programs in the S.A.G.E. (Statistical Analysis for Genetic Epidemiology) program package, but will also cover other programs that are available. Use of these programs determine genetic components of complex traits and writing up reports summarizing the results. Instructor: Robert C. Elston, Ph.D.

EPBI 451 - Principles of Genetic Epidemiology (3)
A survey of the basic principles, concepts and methods of the discipline of genetic epidemiology, which focuses on the role of genetic factors in human disease and their interaction with environmental and cultural factors. Many important human disorders appear to exhibit genetic components; hence the integrated approaches of genetic epidemiology bring together epidemiologic and human genetic perspectives in order to answer critical questions about human disease. Methods of inference based upon data from individuals, pairs of relatives, and pedigrees will be considered. Instructor: Sudha Iyengar, Ph.D. and Robert C. Elston, Ph.D.

EPBI 452 - Statistical Method in Human Genetics (3)
Analytical methods for evaluating the role of genetic factors in human disease, and their interactions with environmental factors. Statistical methods for the estimation of genetic parameters and testing of genetic hypotheses, emphasizing maximum likelihood methods. Models to be considered will include such components as genetic loci of major effect, polygenic inheritance, and environmental, cultural and developmental effects. Topics will include familial aggregation, segregation and linkage analysis, ascertainment, linkage disequilibrium, disease marker association studies, population comparison and twin studies. Instructor: Robert C. Elston, Ph.D. and Rob Igo, Ph.D.

EPBI 454 - Population Genetics for Genetic Epidemiology (3)
This course will cover basics of population genetics (mutation, migration, natural selection) as well as topics such as random mating populations and inbred populations. Emphasis will be placed on migration studies and on linkage disequilibrium mapping. Measures of linkage disequilibrium, methods for linkage disequilibrium mapping of disease genes and the uses of isolated versus outbred populations in linkage disequilibrium mapping will be discussed. Instructor: Xiaofeng Zhu, Ph.D. and Yuqun Luo, Ph.D.

EPBI 455 - Genetic Epidemiology of Common Diseases (3)
Causation and causal inference. Evaluation of genetic epidemiologic study designs. Detailed investigation of the genetic epidemiology of common disorders, such as hypertension, asthma, rheumatoid arthritis, Alzheimer's, schizophrenia, and carcinogenesis.

EPBI 457 - Genetic Linkage Analysis (3).
Methods of analyzing human data to detect genetic linkage between disease traits, discrete and continuous, and polymorphic markers. Both model-based maximum likelihood (Lod score) and model-free robust methods will be discussed. Additional topics covered will include measures of informativeness, multipoint analysis, numerical methods and Mod score analysis. Instructor: Catherine Stein, Ph.D.

EPBI 462 - Computation Methods in Genetic Epidemiology (3)
Methods for computing genetic likelihoods and estimating genetic parameters; Elston-Stewart algorithm, IBD computation; Markov Chain Monte Carlo methods; Newton-Raphson; E-M Algorithm. Instructor: Yuqun Luo, Ph.D.

EPBI 472 - Special Topics in Statistical Genetics (1-4)
Various topics in statistical genetics will be discussed, depending on student interest and needs. Examples of topics are paternity and zygosity testing, path analysis for genetic epidemiology, the analysis of racial admixture and modeling such phenomena as imprinting and anticipation. The course will consist of four modules. A student may, in consultation with the instructor, elect to take 1 - 4 modules for the corresponding amount of credit. Instructor: Various Faculty

EPBI 501 - Student Seminar (0)
Students and faculty have the opportunity to meet on a weekly basis to discuss papers in the literature. Each week a paper is reviewed in detail by a graduate student in a formal presentation. Discussion of the strengths and weaknesses of the work gives insights into the complexities of investigations in the Public Health arena. Instructor: Alfred A. Rimm, Ph.D.

EPBI 502 - Seminar in Genetic Epidemiology (0)
Presentation of original research or recent journal publications in the field of genetic epidemiology by faculty and students. Instructor: Catherine Stein, Ph.D.

EPBI 601 - Masters Project Research (credit as arranged)

EPBI 651 - Thesis M.S. (Credit as arranged)

EPBI 701 - Dissertation Ph.D. (credit as arranged)


Health Services Research Courses
EPBI 408 - Public Policy and Aging (3)
Overview of aging and the aged. Concepts in the study of public policy. Policies on aging and conditions that they address. The politics of policies on aging. Emergent trends and issues. Instructor: Robert Binstock, Ph.D.

EPBI 440 - Seminar in Health Policy (3)
This seminar course provides an overview of the history of the American health care system, current issues facing the health care industry (such as access, cost, and quality), and potential health policy solutions. Discussions will be lead by local experts in the field of health policy and research. The goal of the course is to provide students with a thought-provoking overview of health services delivery which will serve as a foundation for future courses and research.

EPBI 460 - Health Research Methods I (3)
This is a course in research methods which focuses on practical issues in the conduct of epidemiological and health services research studies with an emphasis on survey research methods. Topics include: the interrelationship between theory and research; identifying and formulating epidemiological and health services research questions and hypotheses; research design; sampling strategies; measurement and operationalization; questionnaire design; interviewing, codebook construction; data editing and coding; secondary analysis; issues in the selection of database management and statistical analysis software; and political and ethical influences on research. Instructor: Kathleen A. Smyth, Ph.D.

This course covers the measurement of baseline health status and the processes and outcomes of medical care. Specific methods for describing severity of illness, resource use, appropriateness of care, quality of care, and patient satisfaction are presented. Examples are drawn from hospital care (for example, Diagnosis-Related Groups [DRG's], MEDISGROUPS, and APACHE, and the Appropriateness Evaluation Protocol [AEP]). The focus is on acute-care; issues involved in measuring long-term care and ambulatory care are discussed. Students will gain a conceptual understanding of the systems and practical guidance in selecting, implementing, and evaluating systems. Instructor: E.L. (Mendel) Singer, Ph.D.
Prerequisite: EPBI 460 or consent of instructor.

EPBI 463 - Survey Design and Data Collection (3)
The purpose for this course is to provide hands on experience in designing and conducting surveys in health research. The topics include sampling, types of surveys (e.g. interviews, mail, telephone, medical records), questionnaire design (i.e. multiple indicator models, index and scale construction, assessing psychometrics properties), field operations (i.e. data collection, editing and coding). Instructor: Elaine A. Borawski, Ph.D.

EPBI 464 - Decision Support Systems (3)
Review of methods for decision support in medicine. Review of existing methods for aiding decisions including artificial intelligence and statistical methods to enhance diagnostic accuracy (Bayesian methods, classical multivariate analysis, etc.) Methods for improving the display of information. Theoretical and empirical limitations of these decision aids. Lab exercises include the use of expert system and statistical software.
Prerequisite: MATH 491 or equivalent.

EPBI 465 - Clinical Decision Analysis (3)
This course covers the application of decision trees to clinical problems, estimation and revision of probabilities including Bayes Theorem, utility analysis, cost benefit and cost effectiveness, sensitivity analysis, ROC curves and microcomputer programs for clinical decision analysis.
Prerequisite: Consent of the instructor.

Evaluation of alternative medical treatments and drug therapies. Topics include cost-benefit, cost-effectiveness and cost-utility analysis. Measuring cost, benefits and health outcomes. Quality of life and other measures of effectiveness will also be addressed. Emphasis on case studies, course project, and evaluation of publications. Some decision analysis and policy implications will also be included. Instructor: E.L. (Mendel) Singer, Ph.D.

EPBI 468 - The Continual Improvement of Healthcare: An Interdisciplinary Course (3)
The focus of this course is on collaborative work for the benefit of patients and community. Seminar classwork is combined with a field project, in which interdisciplinary student teams apply what they have learned to the improvement activities of a local health care organization. Successful completion of the course depends on participation in seminar sessions and completion of the interdisciplinary student team project. Instructor: Duncan B. Neuhauser, Ph.D.

EPBI 488 - Gender, Ethnicity, and Health Research (3)
The course is designed to acquaint students with the literature addressing the constructs of race, ethnicity, gender and social class; to examine critically the contexts in which these constructs are often applied; and to assess the relationship between each of these constructs and access to health care, quality of care, and health outcome. Instructor: Sana Loue, Ph.D.

EPBI 489 - Biomedical Perspectives on Women's Health (3)
This course explores constructs of gender, women's access to health care, the quality of women's health care, and women's participation in biomedical research. These themes are examined in the context of various substantive areas, including reproductive health, mental health and illness, cancer, and cardiovascular disease. The course also examines methodological issues in design that are related to gender.

EPBI 501 - Student Seminar (0)
Students and faculty have the opportunity to meet on a weekly basis to discuss papers in the literature. Each week a paper is reviewed in detail by a graduate student in a formal presentation. Discussion of the strengths and weaknesses of the work gives insights into the complexities of investigations in the Public Health arena. Instructor: Alfred A. Rimm, Ph.D.

EPBI 505 - Seminar: Ethical Issues in Research (0)
The twentieth-century biomedical research revolution has produced a variety of ethical, social, and legal controversies. In this course we will discuss important issues related to contemporary research activities. Topics to be addressed include: principles governing experimentation on human beings; special issues raised by randomized clinical trials, phase I trials, innovative therapies, and "rescue" research (e.g., the artificial heart); research on children and other vulnerable populations; gender and racial biases in research; access to experimental treatments for HIV-infected and other seriously ill persons; use of Nazi and other "tainted" research data; and scientific misconduct.

EPBI 515 - Secondary Analysis of Large Health Care Data
Development of skills in working with the large-scale secondary databases generated for research, health care administration/billing, or other purposes. Students will become familiar with the content, strength, and limitations of several databases; with the logistics of obtaining access to databases; the strengths and limitations of routinely collected variables; basic techniques for preparing and analyzing secondary databases and how to apply the techniques to initiate and complete empirical analyses. Instructor: Siran Koroukian, Ph.D.
Prerequisites: EPBI 414 or equivalent; EPBI 460 and EPBI 461 (for HSR students) or EPBI 495 (for EPI students).

EPBI 601 - Masters Project Research (credit as arranged)

EPBI 651 - Thesis M.S. (Credit as arranged)

EPBI 701 - Dissertation Ph.D. (credit as arranged)


Computing Courses
This course is designed to introduce students to the use of computers for development of statistical investigation and provide familiarity with different types of statistical applications and software. Topics include an overview of the UNIX operating system, SAS, and SPSS software packages. Using SAS in the UNIX and Windows environment will be covered in detail. The main focus of this course is to develop skills in data entry, import and export, data manipulation and management, presenting descriptive statistical results and basic data analysis. Familiarity with basic statistics is not required but is useful. Extra topics introducing SAS programming code for advanced statistical analyses will be provided but not included in homework and exams. Instructor: David Bruckman, MS, MT(ASCP)

EPBI 514 - Advanced Statistical Computing (3)
Computational aspects of statistics and statistical modeling, including both graphical and analytic methods. The S programming language. The use of S and other computational tools to explore and analyze data in ways that are difficult to accomplish with standard statistical packages.
Prerequisites: EPBI 414.