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TOMAS RADIVOYEVITCH, PH.D.
Assisstant Professor
Division of Biostatistics
Theoretical radiation biology
Biochemical system analyses of microarray data
Office: School of Medicine, BRB-G19
Phone: (216) 368-1965
E-mail: txr24@case.edu
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- Education
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Ph.D. 1996, Medical University of South Carolina: Environmental Risk Assessment
M.S. 1992, Case Western Reserve University: Chemistry
M.S. 1987, Case Western Reserve University: Systems Engineering
B.S. 1986, Case Western Reserve University: Electrical Engineering
- Research Interests
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Theoretical radiation biology, biochemical system analyses of microarray data.
- Positions
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1986-1987 Teaching Assistant, Systems Engineering, Case, Cleveland, OH
1988-1988 Computer Programmer, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany
1989-1991 Applications Engineer, Bailey Controls Company, Wickliffe, OH
1991-1992 Research Assistant, Chemistry, Case, Cleveland, OH
1992-1993 Teaching Assistant, Biochemistry, Ohio State University, Columbus, OH
1993-1996 Graduate Student, Biometry, MUSC, Charleston, SC
1997-1998 Postdoctoral Fellow, Biometry, MUSC, Charleston, SC
1998-2000 Research Instructor, Biometry, MUSC, Charleston, SC
2000-2001 Visiting Assistant Research Mathematician, University of California, Berkeley,
CA
2001-present Assistant Professor, Epidemiology and Biostatistics, Case, Cleveland, OH
- Selected Peer-Reviewed Publications
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T. Radivoyevitch
and B. Cedervall, Mathematical analysis of DNA fragment distribution
models used with pulsed field gel electrophoresis. Electrophoresis
17, 1087-1093 (1996).
B. Cedervall and T. Radivoyevitch, Methods for analysis
of DNA fragment distributions on pulsed field gel electrophoretic
gels. Electrophoresis 17, 1080-1086 (1996).
T. Radivoyevitch, D. G. Hoel, A. M. Chen and R. K. Sachs,
Misrejoining of double-strand breaks after X-irradiation: Relating
moderate to very high doses by a Markov model. Radiat. Res.
149, 59-67 (1998).
T. Radivoyevitch, D. G. Hoel, P. Hahnfeldt, B. Rydberg
and R. K. Sachs, Recent data obtained by pulsed-field gel
electrophoresis suggest two types of double-strand breaks. Radiat.
Res. 149, 52-58 (1998).
T. Radivoyevitch, D. G. Hoel, P. Hahnfeldt and R. K.
Sachs, Size distributions of misrejoining DNA fragments in irradiated
cells. Math. Biosci. 149, 107-136 (1998).
T. Radivoyevitch, M. J. Ramsey and J. D. Tucker, Estimation
of the target stem cell population size in chronic myeloid leukemogenesis.
Radiat. & Env. Biophys. 38, 201-206(1999).
T. Radivoyevitch and D. G. Hoel, Modeling the low-LET dose-response
of BCR-ABL formation: Predicting stem cell numbers from A-bomb
data. Math. Biosci. 162, 85-101 (1999).
T. Radivoyevitch and D. G. Hoel, Biologically-based risk estimation
for radiation-induced chronic myeloid leukemia. Radiat. &
Env. Biophys. 39, 153-159 (2000).
T. Radivoyevitch, Time course solutions of the Sax-Markov
binary eurejoining/misrejoining model of DNA double-strand breaks.
Radiat. & Env. Biophys. 39, 265-273 (2000).
E. O. Voit and T. Radivoyevitch, Biochemical systems analysis
of genome-wide expression data. Bioinformatics 16,
1023-1037 (2000).
T. Radivoyevitch, S. Kozubek and R. K. Sachs, Biologically-based
risk estimation for radiation-induced CML: Inferences from BCRandABL
geometric distributions. Radiat. & Env. Biophys. 40,
1-9 (2001).
T. Radivoyevitch, The death-mutation model of carcinogenesis.
Mathematical and Computer Modelling 33, 1219-1226
(2001).
T. Radivoyevitch, R. K. Sachs, Y. E. Nikiforov, M. Nikiforova
and M. P. Little, On target cell numbers in radiation-induced
H4-RET mediated papillary thyroid cancer.Radiat.
& Env. Biophys. 40, 191-197 (2001).
T. Radivoyevitch, Sphingoid base metabolism in yeast: Mapping
gene expression patterns into qualitative metabolite time course
predictions. Comparative and Functional Genomics.2,
289-294 (2001).
T. Radivoyevitch, S. Kozubek and R. K. Sachs, The risk of
chronic myeloid leukemia: Can the dose-response curve be U-shaped?
Radiat. Res. 157, 106-109 (2002).
- Research Support
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| | TR Role |
| 5 R01 GM57245-03 Sachs (PI) |
06/01/2000 - 04/30/2001 | 100% |
| NIH/NIGMS | $180,000/yr |
| Chromatin Geometry and Intrachange Proximity Effects |
| The major goal of this project was to analyze large-scale chromosome geometry during cell cycle interphase in light of radiobiological data on chromosome aberrations. |
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| | TR Role |
| DE-FG02-99ER62728 Hoel (PI) |
11/01/1998 - 2/7/2000 | 100% |
| DOE/OBER | $75,000/yr |
| Radiation Leukemogenesis: Applying Basic Science to Epidemiological Estimates of Low Dose Risks and Dose-Rate Effects |
| The major goal of this project was to develop a biologically based model of radiation-induced chronic myeloid leukemia. |
Last Updated: July 13, 2004
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